Basis for high specificity of MSF in brains of rats and monkeys.

Methanesulfonyl Fluoride: A CNS Selective Cholinesterase Inhibitor (1988)

A review paper covering several experiments on rodents and monkeys, this paper showed clearly that the MSF drug had at least three times the effect on the brains of rats as compared to heart and ileum tissue, and pectoral muscle. This was an important point because other drugs that work by the same mechanism were toxic in tissues outside the brain, and had a variety of side effects due to high activity in other tissue. MSF was shown to be nearly unique in the comparison with thirty six other compounds that worked by a similar mechanism in that it had high activity in the brain, and low activity in other tissue.

The paper went on to review a study in monkeys that confirmed the low toxicity of the compound, demonstrating that monkeys injected only started showing side effects at dosages considerably higher than were needed to produce a therapeutic effect.

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