Brain-Tools

Comparison of MSF with other AChE inhibitors shows favorable properties for MSF.

Cholinesterase Inhibitors Proposed for Treating Dementia in Alzheimer’s Disease: Selectivity toward Human Brian Acetylcholinesterase Compared with Butyrylcholinesterase (1995)

Similar to the rat study in paper 1, this experiment took donated human brain matter and treated it with MSF. The goal was to make sure that the compound would preferentially bind its target (Acetylcholinesterase) instead of a similar enzyme (Butyrylcholinesterase). This is important because previous studies had indicated that excessive binding of Butyrylcholinesterase created toxic effects. The study showed that MSF would only bind to its target, while the two competing compounds bound both to the intended and unintended targets.

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